The Zinc-Finger protein ZCCHC3 inhibits LINE-1 retrotransposition

The Zinc-Finger protein ZCCHC3 inhibits LINE-1 retrotransposition

Long-interspersed element 1 (LINE-1) is an autonomous non-LTR retrotransposon. Its replication can cause mutation and rearrangement of host genomic DNA, which may result in serious genetic diseases. Host cells therefore developed defense strategies to restrict LINE-1 mobilization. In this study, we...

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Bibliographic Details
Main Authors: Zixiong Zhang, Ning Zhang, Saisai Guo, Qian Liu, Shujie Wang, Ao Zhang, Dongrong Yi, Jianyuan Zhao, Quanjie Li, Jing Wang, Yongxin Zhang, Ling Ma, Jiwei Ding, Shan Cen, Xiaoyu Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Microbiology
Subjects:
ZCCHC3
LINE-1
retrotransposon
restricting factor
RNA
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.891852/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.891852/full

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