Investigation of CACNA1I Cav3.3 Dysfunction in Hemiplegic Migraine

Investigation of CACNA1I Cav3.3 Dysfunction in Hemiplegic Migraine

Familial hemiplegic migraine (FHM) is a severe neurogenetic disorder for which three causal genes, CACNA1A, SCN1A, and ATP1A2, have been implicated. However, more than 80% of referred diagnostic cases of hemiplegic migraine (HM) are negative for exonic mutations in these known FHM genes, suggesting...

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Bibliographic Details
Main Authors: Neven Maksemous, Claire D. Blayney, Heidi G. Sutherland, Robert A. Smith, Rod A. Lea, Kim Ngan Tran, Omar Ibrahim, Jeffrey R. McArthur, Larisa M. Haupt, M. Zameel Cader, Rocio K. Finol-Urdaneta, David J. Adams, Lyn R. Griffiths
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
hemiplegic migraine
familial hemiplegic migraine
migraine genetics
ion channel
CACNA1I
Cav3.3
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.892820/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2022.892820/full

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