Live recombinant Salmonella Typhi vaccines constructed to investigate the role of rpoS in eliciting immunity to a heterologous antigen.

Live recombinant Salmonella Typhi vaccines constructed to investigate the role of rpoS in eliciting immunity to a heterologous antigen.

We hypothesized that the immunogenicity of live Salmonella enterica serovar Typhi vaccines expressing heterologous antigens depends, at least in part, on its rpoS status. As part of our project to develop a recombinant attenuated S. Typhi vaccine (RASTyV) to prevent pneumococcal diseases in infants...

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Bibliographic Details
Main Authors: Huoying Shi, Javier Santander, Karen E Brenneman, Soo-Young Wanda, Shifeng Wang, Patti Senechal, Wei Sun, Kenneth L Roland, Roy Curtiss
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2887840?pdf=render

Internet

http://europepmc.org/articles/PMC2887840?pdf=render

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