Metformin rescues migratory deficits of cells derived from patients with periventricular heterotopia

Metformin rescues migratory deficits of cells derived from patients with periventricular heterotopia

Abstract Periventricular neuronal heterotopia (PH) is one of the most common forms of cortical malformation in the human cortex. We show that human neuronal progenitor cells (hNPCs) derived from PH patients with a DCHS1 or FAT4 mutation as well as isogenic lines had altered migratory dynamics when g...

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Bibliographic Details
Main Authors: Cedric Bressan, Marta Snapyan, Marina Snapyan, Johannes Klaus, Francesco diMatteo, Stephen P Robertson, Barbara Treutlein, Martin Parent, Silvia Cappello, Armen Saghatelyan
Format: Article
Language:English
Published: Springer Nature 2023-10-01
Series:EMBO Molecular Medicine
Subjects:
autophagy
DCHS1
FAT4
human neural progenitor cells
periventricular neuronal heterotopia
Online Access:https://doi.org/10.15252/emmm.202216908

Internet

https://doi.org/10.15252/emmm.202216908

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