Synthesis and Structure–Activity Relationships for the Anti-Mycobacterial Activity of 3-Phenyl-<i>N</i>-(Pyridin-2-ylmethyl)Pyrazolo[1,5-<i>a</i>]Pyrimidin-7-Amines

Synthesis and Structure–Activity Relationships for the Anti-Mycobacterial Activity of 3-Phenyl-<i>N</i>-(Pyridin-2-ylmethyl)Pyrazolo[1,5-<i>a</i>]Pyrimidin-7-Amines

Pyrazolo[1,5-<i>a</i>]pyrimidines have been reported as potent inhibitors of mycobacterial ATP synthase for the treatment of <i>Mycobacterium tuberculosis</i> (<i>M.tb</i>). In this work, we report the design and synthesis of approximately 70 novel 3,5-diphenyl-&l...

Full description

Bibliographic Details
Main Authors: Hamish S. Sutherland, Peter J. Choi, Guo-Liang Lu, Anna C. Giddens, Amy S. T. Tong, Scott G. Franzblau, Christopher B. Cooper, Brian D. Palmer, William A. Denny
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Pharmaceuticals
Subjects:
pyrazolopyrimidines
structure–activity relationships
synthesis
tuberculosis
ATP synthase
Online Access:https://www.mdpi.com/1424-8247/15/9/1125

Internet

https://www.mdpi.com/1424-8247/15/9/1125

Similar Items