The Trypanosoma brucei MISP family of invariant proteins is co-expressed with BARP as triple helical bundle structures on the surface of salivary gland forms, but is dispensable for parasite development within the tsetse vector.

The Trypanosoma brucei MISP family of invariant proteins is co-expressed with BARP as triple helical bundle structures on the surface of salivary gland forms, but is dispensable for parasite development within the tsetse vector.

Trypanosoma brucei spp. develop into mammalian-infectious metacyclic trypomastigotes inside tsetse salivary glands. Besides acquiring a variant surface glycoprotein (VSG) coat, little is known about the metacyclic expression of invariant surface antigens. Proteomic analyses of saliva from T. brucei-...

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Bibliographic Details
Main Authors: Aitor Casas-Sanchez, Raghavendran Ramaswamy, Samïrah Perally, Lee R Haines, Clair Rose, Marcela Aguilera-Flores, Susana Portillo, Margot Verbeelen, Shahid Hussain, Laura Smithson, Cristina Yunta, Michael J Lehane, Sue Vaughan, Jan van den Abbeele, Igor C Almeida, Martin J Boulanger, Álvaro Acosta-Serrano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011269

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https://doi.org/10.1371/journal.ppat.1011269

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