Modulation of p53 expression in cancer-associated fibroblasts prevents peritoneal metastasis of gastric cancer

Modulation of p53 expression in cancer-associated fibroblasts prevents peritoneal metastasis of gastric cancer

Cancer-associated fibroblasts (CAFs) in the tumor microenvironment are associated with the establishment and progression of peritoneal metastasis. This study investigated the efficacy of replicative oncolytic adenovirus-mediated p53 gene therapy (OBP-702) against CAFs and peritoneal metastasis of ga...

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Bibliographic Details
Main Authors: Toshihiro Ogawa, Satoru Kikuchi, Motoyasu Tabuchi, Ema Mitsui, Yuta Une, Hiroshi Tazawa, Shinji Kuroda, Kazuhiro Noma, Toshiaki Ohara, Shunsuke Kagawa, Yasuo Urata, Toshiyoshi Fujiwara
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Molecular Therapy: Oncolytics
Subjects:
peritoneal metastasis
adenovirus
gastric cancer
cancer-associated fibroblast
p53
oncolytic virus
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770522000614

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http://www.sciencedirect.com/science/article/pii/S2372770522000614

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