Developing methods to study conformational changes in RNA crystals using a photocaged ligand

Developing methods to study conformational changes in RNA crystals using a photocaged ligand

Crystallographic observation of structural changes in real time requires that those changes be uniform both spatially and temporally. A primary challenge with time-resolved ligand-mixing diffraction experiments is asynchrony caused by variable factors, such as efficiency of mixing, rate of diffusion...

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Bibliographic Details
Main Authors: Hyun Kyung Lee, Chelsie E. Conrad, Valentin Magidson, William F. Heinz, Gary Pauly, Ping Yu, Saminathan Ramakrishnan, Jason R. Stagno, Yun-Xing Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
crystal phase transition
photocaged ligand
photo-induced
RNA
riboswitch
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.964595/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.964595/full

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