Progress in understanding the role of cGAS-STING pathway associated with programmed cell death in intervertebral disc degeneration

Progress in understanding the role of cGAS-STING pathway associated with programmed cell death in intervertebral disc degeneration

Abstract Nucleus pulposus (NP) inflammatory response can induce intervertebral disc degeneration (IVDD) by causing anabolic and catabolic disequilibrium of the extracellular matrix (ECM). This process is accompanied by the production of endogenous DNAs, then detectable by the DNA sensor cyclic GMP-A...

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Bibliographic Details
Main Authors: Zheng Wang, Xinli Hu, Peng Cui, Chao Kong, Xiaolong Chen, Wei Wang, Shibao Lu
Format: Article
Language:English
Published: Nature Publishing Group 2023-10-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01607-7

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https://doi.org/10.1038/s41420-023-01607-7

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