Therapeutic Targeting of ALK in Neuroblastoma: Experience of Italian Precision Medicine in Pediatric Oncology

Therapeutic Targeting of ALK in Neuroblastoma: Experience of Italian Precision Medicine in Pediatric Oncology

Neuroblastoma (NB) is the most common extracranial solid tumor in childhood. Patients with relapsed/refractory disease have a poor prognosis, and additional therapeutic options are needed. Mutations and amplifications in the <i>ALK</i> (Anaplastic Lymphoma Kinase) gene constitute a key t...

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Bibliographic Details
Main Authors: Fabio Pastorino, Mario Capasso, Chiara Brignole, Vito A. Lasorsa, Veronica Bensa, Patrizia Perri, Sueva Cantalupo, Serena Giglio, Massimo Provenzi, Marco Rabusin, Elvira Pota, Monica Cellini, Annalisa Tondo, Maria A. De Ioris, Angela R. Sementa, Alberto Garaventa, Mirco Ponzoni, Loredana Amoroso
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cancers
Subjects:
anaplastic lymphoma kinase
target therapy
tyrosine kinase inhibitor
whole-exome sequencing
neuroblastoma
precision medicine
Online Access:https://www.mdpi.com/2072-6694/15/3/560

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https://www.mdpi.com/2072-6694/15/3/560

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