Targeting Integrin α3 Blocks β1 Maturation, Triggers Endoplasmic Reticulum Stress, and Sensitizes Glioblastoma Cells to TRAIL-Mediated Apoptosis

Targeting Integrin α3 Blocks β1 Maturation, Triggers Endoplasmic Reticulum Stress, and Sensitizes Glioblastoma Cells to TRAIL-Mediated Apoptosis

Glioblastoma (GBM) is a devastating brain cancer for which new effective therapies are urgently needed. GBM, after an initial response to current treatment regimens, develops therapeutic resistance, leading to rapid patient demise. Cancer cells exhibit an inherent elevation of endoplasmic reticulum...

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Bibliographic Details
Main Authors: Yuki Kuranaga, Bing Yu, Satoru Osuka, Hanwen Zhang, Narra S. Devi, Sejong Bae, Erwin G. Van Meir
Format: Article
Language:English
Published: MDPI AG 2024-04-01
Series:Cells
Subjects:
brain tumor
glioblastoma
integrin
ER stress
death receptor 5
Online Access:https://www.mdpi.com/2073-4409/13/9/753

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https://www.mdpi.com/2073-4409/13/9/753

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