Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei

Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei

Abstract Background Facioscapulohumeral muscular dystrophy (FSHD) is associated with DNA hypomethylation at the 4q35 D4Z4 repeat array. Both the causal gene DUX4 and its homolog DUX4c are induced. DUX4c is immunodetected in every myonucleus of proliferative cells, while DUX4 is present in only 1/100...

Full description

Bibliographic Details
Main Authors: Céline Vanderplanck, Alexandra Tassin, Eugénie Ansseau, Sébastien Charron, Armelle Wauters, Céline Lancelot, Kelly Vancutsem, Dalila Laoudj-Chenivesse, Alexandra Belayew, Frédérique Coppée
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Skeletal Muscle
Subjects:
Disorganized myotubes
Myonuclear clustering
Cytoskeleton
β-catenin
Proliferation
Differentiation
Online Access:http://link.springer.com/article/10.1186/s13395-017-0148-4

Internet

http://link.springer.com/article/10.1186/s13395-017-0148-4

Similar Items