mTOR Repression in Response to Amino Acid Starvation Promotes ECM Degradation Through MT1‐MMP Endocytosis Arrest

mTOR Repression in Response to Amino Acid Starvation Promotes ECM Degradation Through MT1‐MMP Endocytosis Arrest

Abstract Under conditions of starvation, normal and tumor epithelial cells can rewire their metabolism toward the consumption of extracellular proteins, including extracellular matrix‐derived components as nutrient sources. The mechanism of pericellular matrix degradation by starved cells has been l...

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Bibliographic Details
Main Authors: Cecilia Colombero, David Remy, Sandra Antoine‐Bally, Anne‐Sophie Macé, Pedro Monteiro, Nadia ElKhatib, Margot Fournier, Ahmed Dahmani, Elodie Montaudon, Guillaume Montagnac, Elisabetta Marangoni, Philippe Chavrier
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:Advanced Science
Subjects:
breast cancer
clathrin‐mediated endocytosis
extracellular matrix
invadopodia
MT1‐MMP
mTOR
Online Access:https://doi.org/10.1002/advs.202101614

Internet

https://doi.org/10.1002/advs.202101614

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