Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Induced Leukocyte Migration

Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Induced Leukocyte Migration

Although chemokines are sufficient for chemotaxis of various cells, increasing evidence exists for their fine-tuning by selective proteolytic processing. Using a model of immune cell chemotaxis into the CNS (experimental autoimmune encephalomyelitis [EAE]) that permits precise localization of immigr...

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Bibliographic Details
Main Authors: Jian Song, Chuan Wu, Eva Korpos, Xueli Zhang, Smriti M. Agrawal, Ying Wang, Cornelius Faber, Michael Schäfers, Heinrich Körner, Ghislain Opdenakker, Rupert Hallmann, Lydia Sorokin
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715000625

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http://www.sciencedirect.com/science/article/pii/S2211124715000625

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