Determining the effective dose of esketamine for mitigating pain during propofol injection by Dixon’s up-and-down method: a double-blind, prospective clinical study of drug dose response

Determining the effective dose of esketamine for mitigating pain during propofol injection by Dixon’s up-and-down method: a double-blind, prospective clinical study of drug dose response

Abstract Background Propofol is an intravenous (IV) anesthetic medication widely used for procedural sedation, operative anesthesia, and in intensive care unit (ICU), but the incidence of pain during IV infusion can reach 28–90%. Ketamine can attenuate pain associated with IV propofol injection thro...

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Bibliographic Details
Main Authors: Meiyun Tan, Chunyuan Zhang, Wei Zeng, Maofang Chen, Zehui Huang, Ding Huang
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Anesthesiology
Subjects:
Esketamine
Propofol injection pain
Effective dose
Online Access:https://doi.org/10.1186/s12871-022-01914-z

Internet

https://doi.org/10.1186/s12871-022-01914-z

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