Towards safer anti-inflammatory therapy: synthesis of new thymol–pyrazole hybrids as dual COX-2/5-LOX inhibitors

Towards safer anti-inflammatory therapy: synthesis of new thymol–pyrazole hybrids as dual COX-2/5-LOX inhibitors

AbstractNew thymol − 1,5-disubstitutedpyrazole hybrids were synthesised as dual COX-2/5-LOX inhibitors. Compounds 8b, 8g, 8c, and 4a displayed in vitro inhibitory activity against COX-2 (IC50 = 0.043, 0.045, 0.063, and 0.068 µM) nearly equal to celecoxib (IC50 = 0.045 µM) with high SI (316, 268, 204...

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Bibliographic Details
Main Authors: Mostafa M. M. El-Miligy, Ahmed K. Al-Kubeisi, Mohamed G. Bekhit, Saad R. El-Zemity, Rasha A. Nassra, Aly A. Hazzaa
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Thymol
pyrazole
anti-inflammatory
COX-2
5-LOX
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2022.2147164

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2022.2147164

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