Towards safer anti-inflammatory therapy: synthesis of new thymol–pyrazole hybrids as dual COX-2/5-LOX inhibitors
New thymol − 1,5-disubstitutedpyrazole hybrids were synthesised as dual COX-2/5-LOX inhibitors. Compounds 8b, 8g, 8c, and 4a displayed in vitro inhibitory activity against COX-2 (IC50 = 0.043, 0.045, 0.063, and 0.068 µM) nearly equal to celecoxib (IC50 = 0.045 µM) with high SI (316, 268, 204, and 15...
主要な著者: | , , , , , |
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フォーマット: | 論文 |
言語: | English |
出版事項: |
Taylor & Francis Group
2023-12-01
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シリーズ: | Journal of Enzyme Inhibition and Medicinal Chemistry |
主題: | |
オンライン・アクセス: | https://www.tandfonline.com/doi/10.1080/14756366.2022.2147164 |