Novel Helical Trp‐ and Arg‐Rich Antimicrobial Peptides Locate Near Membrane Surfaces and Rigidify Lipid Model Membranes

Novel Helical Trp‐ and Arg‐Rich Antimicrobial Peptides Locate Near Membrane Surfaces and Rigidify Lipid Model Membranes

Antibiotics are losing effectiveness as bacteria become resistant to conventional drugs. To find new alternatives, antimicrobial peptides (AMPs) are rationally designed with different lengths, charges, hydrophobicities (H), and hydrophobic moments (μH), containing only three types of amino acids: ar...

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Bibliographic Details
Main Authors: Saheli Mitra, Mark Coopershlyak, Yunshu Li, Bhairavi Chandersekhar, Rachel Koenig, Mei-Tung Chen, Brandt Evans, Frank Heinrich, Berthony Deslouches, Stephanie Tristram-Nagle
Format: Article
Language:English
Published: Wiley-VCH 2023-05-01
Series:Advanced NanoBiomed Research
Subjects:
antimicrobial peptides (AMPs)
circular dichroism (CD)
elasticity
Gram-negative bacteria
Gram-positive bacteria
minimum inhibitory concentration (MIC)
Online Access:https://doi.org/10.1002/anbr.202300013

Internet

https://doi.org/10.1002/anbr.202300013

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