Circ_0020256 induces fibroblast activation to drive cholangiocarcinoma development via recruitment of EIF4A3 protein to stabilize KLF4 mRNA

Circ_0020256 induces fibroblast activation to drive cholangiocarcinoma development via recruitment of EIF4A3 protein to stabilize KLF4 mRNA

Abstract Cancer-associated fibroblasts (CAFs) are a kind of stromal cells in the cholangiocarcinoma (CCA) microenvironment, playing crucial roles in cancer development. However, the potential mechanisms of the interaction between CCA cells and CAFs remain obscure. This work investigated the role of...

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Bibliographic Details
Main Authors: Zongyan Li, Zuxiao Chen, Shiying Li, Xiangjun Qian, Lei Zhang, Guojie Long, Jiancong Xie, Xiaoming Huang, Zheyu Zheng, Weidong Pan, Haiyan Li, Dawei Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2023-05-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01439-5

Internet

https://doi.org/10.1038/s41420-023-01439-5

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