Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection

Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection

Abstract HIV/SIV infections lead to massive loss of mucosal CD4 + T cells and breakdown of the epithelial mucosa resulting in severe microbial dysbiosis and chronic immune activation that ultimately drive disease progression. Moreover, disruption of one of the most understudied mucosal environments,...

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Bibliographic Details
Main Authors: Rhianna Jones, Kyle Kroll, Courtney Broedlow, Luca Schifanella, Scott Smith, Brady Hueber, Spandan V. Shah, Daniel R. Ram, Cordelia Manickam, Valerie Varner, Nichole R. Klatt, R. Keith Reeves
Format: Article
Language:English
Published: Nature Portfolio 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-93918-x

Internet

https://doi.org/10.1038/s41598-021-93918-x

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