Clinical outcomes following discontinuation of metformin in patients with type 2 diabetes and advanced chronic kidney disease in Hong Kong: a territory-wide, retrospective cohort and target trial emulation studyResearch in context

Clinical outcomes following discontinuation of metformin in patients with type 2 diabetes and advanced chronic kidney disease in Hong Kong: a territory-wide, retrospective cohort and target trial emulation studyResearch in context

Summary: Background: Current labelling advises discontinuation of metformin when estimated glomerular filtration rate (eGFR) < 30 ml/min/1.73 m2 due to increased risk of lactic acidosis. However, in real-world practice, the risk-benefit ratios remain uncertain. We examined the risk associations...

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Bibliographic Details
Main Authors: Aimin Yang, Mai Shi, Hongjiang Wu, Eric SH. Lau, Johnny TK. Cheung, Xinge Zhang, Baoqi Fan, Tingting Chen, Alice PS. Kong, Andrea OY. Luk, Ronald CW. Ma, Juliana CN. Chan, Elaine Chow
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:EClinicalMedicine
Subjects:
Metformin
Cardiovascular disease
Mortality
Therapeutics
Diabetes
Chronic kidney disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537024001470

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http://www.sciencedirect.com/science/article/pii/S2589537024001470

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