Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis

Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis

Abstract Background Microglia are major players in the pathogenesis of multiple sclerosis (MS) and may play a dual role in disease progression. The activation status of microglia in vivo is highly dynamic and occurs as a continuum, with the pro-inflammatory and anti-inflammatory phenotypes on either...

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Bibliographic Details
Main Authors: Wissam Beaino, Bieneke Janssen, Gijs Kooij, Susanne M. A. van der Pol, B. van Het Hof, Jack van Horssen, Albert D. Windhorst, Helga E. de Vries
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Journal of Neuroinflammation
Subjects:
Multiple sclerosis
P2Y12R
P2X7R
PET imaging
Neuroinflammation
Microglia
Online Access:http://link.springer.com/article/10.1186/s12974-017-1034-z

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http://link.springer.com/article/10.1186/s12974-017-1034-z

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