Comparative pharmacokinetics of polymyxin B in critically ill elderly patients with extensively drug-resistant gram-negative bacteria infections

Comparative pharmacokinetics of polymyxin B in critically ill elderly patients with extensively drug-resistant gram-negative bacteria infections

Introduction: Elderly patients are more prone to develop acute kidney injury during infections and polymyxin B (PMB)-associated nephrotoxicity than young patients. The differential response to PMB between the elderly and young critically ill patients is unknown. We aimed to assess PMB exposure in el...

Full description

Bibliographic Details
Main Authors: Juan Zeng, Bing Leng, Xiaoyan Guan, Shuangyan Jiang, Maoyu Xie, Wenying Zhu, Yue Tang, Lin Zhang, Jing Sha, Tengfei Wang, Min Ding, Nan Guo, Jinjiao Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Pharmacology
Subjects:
polymyxin B
pharmacokinetics
elderly
critical care
total body weight
renal function
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1347130/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1347130/full

Similar Items