XPC deficiency increases risk of hematologic malignancies through mutator phenotype and characteristic mutational signature
Xeroderma Pigmentosum group C (XP-C) is a rare genetic disorder characterised by deficient DNA repair leading to skin and internal cancer, but the latter is not well understood molecularly. Here the authors sequence genomes of non-skin cancers from XP-C patients to unravel its mutational patterns.
| Päätekijät: | , , , , , |
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| Aineistotyyppi: | Artikkeli |
| Kieli: | English |
| Julkaistu: |
Nature Portfolio
2020-11-01
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| Sarja: | Nature Communications |
| Linkit: | https://doi.org/10.1038/s41467-020-19633-9 |