Targeting USP8 Inhibits O‐GlcNAcylation of SLC7A11 to Promote Ferroptosis of Hepatocellular Carcinoma via Stabilization of OGT

Targeting USP8 Inhibits O‐GlcNAcylation of SLC7A11 to Promote Ferroptosis of Hepatocellular Carcinoma via Stabilization of OGT

Abstract Hepatocellular carcinoma (HCC) is a lethal and aggressive human malignancy. The present study examins the anti‐tumor effects of deubiquitylating enzymes (DUB) inhibitors in HCC. It is found that the inhibitor of ubiquitin specific peptidase 8 (USP8) and DUB‐IN‐3 shows the most effective ant...

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Bibliographic Details
Main Authors: Jianing Tang, Guo Long, Kuan Hu, Desheng Xiao, Shuang Liu, Liang Xiao, Ledu Zhou, Yongguang Tao
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:Advanced Science
Subjects:
deubiquitylation
ferroptosis
O‐GlcNAcylation
OGT
USP8
Online Access:https://doi.org/10.1002/advs.202302953

Internet

https://doi.org/10.1002/advs.202302953

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