Semaphorin 7A interacts with nuclear factor NF-kappa-B p105 via integrin β1 and mediates inflammation

Semaphorin 7A interacts with nuclear factor NF-kappa-B p105 via integrin β1 and mediates inflammation

Abstract Semaphorin7a (SEMA7A), a membrane-anchored member of the semaphorin protein family, could be involved in a diverse range of immune responses via its receptor integrin β1. Recently, we reported that the SEMA7A R148W mutation (a gain-of-function mutation, Sema7a R145W in mice) is a risk facto...

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Bibliographic Details
Main Authors: Xuan Li, Wanlu Xie, Qiong Pan, Xiaoxun Zhang, Liangjun Zhang, Nan Zhao, Qiaoling Xie, Jingjing Ding, Jin Chai
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Cell Communication and Signaling
Subjects:
Semaphorin7a
NF-kappa-B p105
NF-kappa-B p65
Integrin β1
Inflammation
Online Access:https://doi.org/10.1186/s12964-022-01024-w

Internet

https://doi.org/10.1186/s12964-022-01024-w

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