Induction of AML Preleukemic Fusion Genes in HSPCs and DNA Damage Response in Preleukemic Fusion Gene Positive Samples

Induction of AML Preleukemic Fusion Genes in HSPCs and DNA Damage Response in Preleukemic Fusion Gene Positive Samples

Preleukemic fusion genes (PFGs) occurring after DNA damage in hematopoietic stem progenitor cells (HSPCs) in utero often represent the initial event in the development of childhood leukemia. While the incidence of PFGs characteristic for acute lymphoblastic leukemia (ALL) was relatively well examine...

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Bibliographic Details
Main Authors: Pavol Kosik, Matus Durdik, Milan Skorvaga, Daniela Klimova, Dominika Kochanova, Zlatica Cerna, Miroslav Kubes, Marek Holop, Igor Belyaev
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Antioxidants
Subjects:
leukemia
preleukemic fusion genes
DNA damage
ionizing radiation
hematopoietic stem progenitor cells
Online Access:https://www.mdpi.com/2076-3921/10/3/481

Internet

https://www.mdpi.com/2076-3921/10/3/481

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