Pilicide ec240 Disrupts Virulence Circuits in Uropathogenic <named-content content-type="genus-species">Escherichia coli</named-content>

Pilicide ec240 Disrupts Virulence Circuits in Uropathogenic <named-content content-type="genus-species">Escherichia coli</named-content>

ABSTRACT Chaperone-usher pathway (CUP) pili are extracellular organelles produced by Gram-negative bacteria that mediate bacterial pathogenesis. Small-molecule inhibitors of CUP pili, termed pilicides, were rationally designed and shown to inhibit type 1 or P piliation. Here, we show that pilicide e...

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Bibliographic Details
Main Authors: Sarah E. Greene, Jerome S. Pinkner, Erik Chorell, Karen W. Dodson, Carrie L. Shaffer, Matt S. Conover, Jonathan Livny, Maria Hadjifrangiskou, Fredrik Almqvist, Scott J. Hultgren
Format: Article
Language:English
Published: American Society for Microbiology 2014-12-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.02038-14

Internet

https://journals.asm.org/doi/10.1128/mBio.02038-14

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