Mitochondrial Signature in Human Monocytes and Resistance to Infection in C. elegans During Fumarate-Induced Innate Immune Training

Mitochondrial Signature in Human Monocytes and Resistance to Infection in C. elegans During Fumarate-Induced Innate Immune Training

Monocytes can develop immunological memory, a functional characteristic widely recognized as innate immune training, to distinguish it from memory in adaptive immune cells. Upon a secondary immune challenge, either homologous or heterologous, trained monocytes/macrophages exhibit a more robust produ...

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Bibliographic Details
Main Authors: C. Angélica Pérez-Hernández, Carina C. Kern, Egle Butkeviciute, Elizabeth McCarthy, Hazel M. Dockrell, María Maximina Bertha Moreno-Altamirano, Bruno A. Aguilar-López, Gauri Bhosale, Hongyuan Wang, David Gems, Michael R. Duchen, Steven G. Smith, Francisco Javier Sánchez-García
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
innate immunity
immune training
mitochondria
monocytes
C. elegans
infection
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01715/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01715/full

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