Intranuclear Positions of HIV-1 Proviruses Are Dynamic and Do Not Correlate with Transcriptional Activity

Intranuclear Positions of HIV-1 Proviruses Are Dynamic and Do Not Correlate with Transcriptional Activity

ABSTRACT The relationship between spatiotemporal distribution of HIV-1 proviruses and their transcriptional activity is not well understood. To elucidate the intranuclear positions of transcriptionally active HIV-1 proviruses, we utilized an RNA fluorescence in situ hybridization assay and RNA stem...

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Bibliographic Details
Main Authors: Ryan C. Burdick, Claire Deleage, Alice Duchon, Jacob D. Estes, Wei-Shau Hu, Vinay K. Pathak
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:mBio
Subjects:
HIV-1
capsid
CPSF6
integration
transcription
Online Access:https://journals.asm.org/doi/10.1128/mbio.03256-21

Internet

https://journals.asm.org/doi/10.1128/mbio.03256-21

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