Resistant Maltodextrin Intake Reduces Virulent Metabolites in the Gut Environment: A Randomized Control Study in a Japanese Cohort
In recent years, there have been many reports on the effects of prebiotics on intestinal health. In particular, the consumption of resistant maltodextrin (RMD) has been reported to be beneficial. However, there has been no comprehensive quantification of the effect of RMD on the intestinal environme...
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.644146/full |
| _version_ | 1818541131547279360 |
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| author | Yuichiro Nishimoto Yoshinori Mizuguchi Yuka Mori Masaki Ito Shoko Miyazato Yuka Kishimoto Takuji Yamada Takuji Yamada Shinji Fukuda Shinji Fukuda Shinji Fukuda Shinji Fukuda |
| author_facet | Yuichiro Nishimoto Yoshinori Mizuguchi Yuka Mori Masaki Ito Shoko Miyazato Yuka Kishimoto Takuji Yamada Takuji Yamada Shinji Fukuda Shinji Fukuda Shinji Fukuda Shinji Fukuda |
| author_sort | Yuichiro Nishimoto |
| collection | DOAJ |
| description | In recent years, there have been many reports on the effects of prebiotics on intestinal health. In particular, the consumption of resistant maltodextrin (RMD) has been reported to be beneficial. However, there has been no comprehensive quantification of the effect of RMD on the intestinal environment. Therefore, this study aimed to quantify the effects of RMD on the intestine, especially the intestinal microbiome and metabolome profiles. A randomized, double-blind, and controlled trial was conducted in 29 Japanese subjects, whose hemoglobin A1c (HbA1c) levels are larger than 6% (Clinical trial no. UMIN000023970, https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000027589). The subjects consumed RMD or placebo twice per day for 24 weeks. Blood and fecal samples were collected before and after the intake. The intestinal environment was assessed by a metabologenomics approach, involving 16S rRNA gene-based microbiome analysis and mass spectrometry-based metabolome analysis. The intake of RMD increased the levels of Bifidobacterium and Fusicatenibacter and decreased deoxycholate levels. Additionally, intake of RMD lowered the levels of some opportunistic virulent metabolites, such as imidazole propionate and trimethylamine, in subjects with an initially high amount of those metabolites. RMD may have beneficial effects on the gut environment, such as commensal microbiota modulation and reduction of virulence metabolites, which is known as a causative factor in metabolic disorders. However, the effects of RMD partially depend on the gut environmental baseline. |
| first_indexed | 2024-12-11T22:04:33Z |
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| id | doaj.art-48722fd0e6a64fe6aa45ad06b1f6f02c |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-11T22:04:33Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-48722fd0e6a64fe6aa45ad06b1f6f02c2022-12-22T00:49:00ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-05-011310.3389/fmicb.2022.644146644146Resistant Maltodextrin Intake Reduces Virulent Metabolites in the Gut Environment: A Randomized Control Study in a Japanese CohortYuichiro Nishimoto0Yoshinori Mizuguchi1Yuka Mori2Masaki Ito3Shoko Miyazato4Yuka Kishimoto5Takuji Yamada6Takuji Yamada7Shinji Fukuda8Shinji Fukuda9Shinji Fukuda10Shinji Fukuda11Metagen Inc., Tsuruoka, JapanMetagen Inc., Tsuruoka, JapanMetagen Inc., Tsuruoka, JapanMetagen Inc., Tsuruoka, JapanMatsutani Chemical Industry Co., Ltd., Itami, JapanMatsutani Chemical Industry Co., Ltd., Itami, JapanMetagen Inc., Tsuruoka, JapanDepartment of Life Science and Technology, Tokyo Institute of Technology, Tokyo, JapanMetagen Inc., Tsuruoka, JapanInstitute for Advanced Biosciences, Keio University, Tsuruoka, JapanIntestinal Microbiota Project, Kanagawa Institute of Industrial Science and Technology, Kawasaki, JapanTransborder Medical Research Center, University of Tsukuba, Tsukuba, JapanIn recent years, there have been many reports on the effects of prebiotics on intestinal health. In particular, the consumption of resistant maltodextrin (RMD) has been reported to be beneficial. However, there has been no comprehensive quantification of the effect of RMD on the intestinal environment. Therefore, this study aimed to quantify the effects of RMD on the intestine, especially the intestinal microbiome and metabolome profiles. A randomized, double-blind, and controlled trial was conducted in 29 Japanese subjects, whose hemoglobin A1c (HbA1c) levels are larger than 6% (Clinical trial no. UMIN000023970, https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000027589). The subjects consumed RMD or placebo twice per day for 24 weeks. Blood and fecal samples were collected before and after the intake. The intestinal environment was assessed by a metabologenomics approach, involving 16S rRNA gene-based microbiome analysis and mass spectrometry-based metabolome analysis. The intake of RMD increased the levels of Bifidobacterium and Fusicatenibacter and decreased deoxycholate levels. Additionally, intake of RMD lowered the levels of some opportunistic virulent metabolites, such as imidazole propionate and trimethylamine, in subjects with an initially high amount of those metabolites. RMD may have beneficial effects on the gut environment, such as commensal microbiota modulation and reduction of virulence metabolites, which is known as a causative factor in metabolic disorders. However, the effects of RMD partially depend on the gut environmental baseline.https://www.frontiersin.org/articles/10.3389/fmicb.2022.644146/fullprebioticsgut microbiotaintestinal metabolitesdietary fiberresistant maltodextrin |
| spellingShingle | Yuichiro Nishimoto Yoshinori Mizuguchi Yuka Mori Masaki Ito Shoko Miyazato Yuka Kishimoto Takuji Yamada Takuji Yamada Shinji Fukuda Shinji Fukuda Shinji Fukuda Shinji Fukuda Resistant Maltodextrin Intake Reduces Virulent Metabolites in the Gut Environment: A Randomized Control Study in a Japanese Cohort Frontiers in Microbiology prebiotics gut microbiota intestinal metabolites dietary fiber resistant maltodextrin |
| title | Resistant Maltodextrin Intake Reduces Virulent Metabolites in the Gut Environment: A Randomized Control Study in a Japanese Cohort |
| title_full | Resistant Maltodextrin Intake Reduces Virulent Metabolites in the Gut Environment: A Randomized Control Study in a Japanese Cohort |
| title_fullStr | Resistant Maltodextrin Intake Reduces Virulent Metabolites in the Gut Environment: A Randomized Control Study in a Japanese Cohort |
| title_full_unstemmed | Resistant Maltodextrin Intake Reduces Virulent Metabolites in the Gut Environment: A Randomized Control Study in a Japanese Cohort |
| title_short | Resistant Maltodextrin Intake Reduces Virulent Metabolites in the Gut Environment: A Randomized Control Study in a Japanese Cohort |
| title_sort | resistant maltodextrin intake reduces virulent metabolites in the gut environment a randomized control study in a japanese cohort |
| topic | prebiotics gut microbiota intestinal metabolites dietary fiber resistant maltodextrin |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.644146/full |
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