An Exploration of Small Molecules That Bind Human Single-Stranded DNA Binding Protein 1

An Exploration of Small Molecules That Bind Human Single-Stranded DNA Binding Protein 1

Human single-stranded DNA binding protein 1 (hSSB1) is critical to preserving genome stability, interacting with single-stranded DNA (ssDNA) through an oligonucleotide/oligosaccharide binding-fold. The depletion of hSSB1 in cell-line models leads to aberrant DNA repair and increased sensitivity to i...

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Bibliographic Details
Main Authors: Zachariah P. Schuurs, Alexander P. Martyn, Carl P. Soltau, Sam Beard, Esha T. Shah, Mark N. Adams, Laura V. Croft, Kenneth J. O’Byrne, Derek J. Richard, Neha S. Gandhi
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Biology
Subjects:
hSSB1
oligonucleotide/oligosaccharide binding-fold
DNA repair
structure-based drug design
ssDNA interactions
Online Access:https://www.mdpi.com/2079-7737/12/11/1405

Internet

https://www.mdpi.com/2079-7737/12/11/1405

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