Sacubitril/valsartan (LCZ696) ameliorates hyperthyroid-induced cardiac hypertrophy in male rats through modulation of miR-377, let-7 b, autophagy, and fibrotic signaling pathways
Abstract Hyperthyroidism is associated with cardiac hypertrophy, fibrosis, and increased risk of cardiovascular mortality. Sacubitril/valsartan (LCZ696) is a new combined drug that has shown promise for the treatment of hyperthyroidism-associated heart failure; however, the underlying molecular mech...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-08-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-022-18860-y |