α-Synucleinopathy associated c-Abl activation causes p53-dependent autophagy impairment

α-Synucleinopathy associated c-Abl activation causes p53-dependent autophagy impairment

Abstract Background Studies link c-Abl activation with the accumulation of pathogenic α-synuclein (αS) and neurodegeneration in Parkinson’s disease (PD). Currently, c-Abl, a tyrosine kinase activated by cellular stress, is thought to promote αS pathology by either directly phosphorylating αS or by c...

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Bibliographic Details
Main Authors: Md. Razaul Karim, Elly E. Liao, Jaekwang Kim, Joyce Meints, Hector Martell Martinez, Olga Pletnikova, Juan C. Troncoso, Michael K. Lee
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Molecular Neurodegeneration
Subjects:
Neurodegeneration
Parkinson’s disease (PD)
α-Synuclein
C-Abl
p53
Autophagy
Online Access:http://link.springer.com/article/10.1186/s13024-020-00364-w

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http://link.springer.com/article/10.1186/s13024-020-00364-w

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