SIRT6 pharmacological inhibition delays skin cancer progression in the squamous cell carcinoma

SIRT6 pharmacological inhibition delays skin cancer progression in the squamous cell carcinoma

Sirtuin 6 (SIRT6) has a critical role in cutaneous Squamous Cell Carcinoma (cSCC): SIRT6 silencing in skin SCC cells has pro-differentiating effects and SIRT6 deletion abrogated DMBA-TPA-induced skin tumorigenesis in mice. On the other hand, SIRT6 acts as tumor suppressor in SCC by enhancing glycoly...

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Bibliographic Details
Main Authors: Elena Abbotto, Caterina Miro, Francesco Piacente, Annalisa Salis, Melania Murolo, Annarita Nappi, Enrico Millo, Eleonora Russo, Elena Cichero, Laura Sturla, Alberto Del Rio, Antonio De Flora, Alessio Nencioni, Monica Dentice, Santina Bruzzone
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Sirtuin 6
Squamous cell carcinoma
DMBA-TPA mouse model
Pharmacological modulation
Epithelial-mesenchymal transition
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223011174

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http://www.sciencedirect.com/science/article/pii/S0753332223011174

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