Obesity Mediates Apoptosis and Extracellular Matrix Metabolic Imbalances via MAPK Pathway Activation in Intervertebral Disk Degeneration

Obesity Mediates Apoptosis and Extracellular Matrix Metabolic Imbalances via MAPK Pathway Activation in Intervertebral Disk Degeneration

Obesity may promote intervertebral disc degeneration (IDD) by non-mechanical means, by influencing levels of free fatty acids which could impair cell metabolism. This study aims to establish metabolic factors in obesity-related IDD independent of mechanical loading. In clinical study, we retrospecti...

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Detalhes bibliográficos
Main Authors: Xuyang Zhang, Jian Chen, Bao Huang, Jiasheng Wang, Zhi Shan, Junhui Liu, Yilei Chen, Shengyun Li, Shunwu Fan, Fengdong Zhao
Formato: Artigo
Idioma:English
Publicado em: Frontiers Media S.A. 2019-10-01
Colecção:Frontiers in Physiology
Assuntos:
obesity
apoptosis
extracellular matrix
MAPK pathway
intervertebral disk degeneration
Acesso em linha:https://www.frontiersin.org/article/10.3389/fphys.2019.01284/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.01284/full

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