Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities

Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities

Palladin (PALLD) belongs to the PALLD/myopalladin (MYPN)/myotilin family of actin-associated immunoglobulin-containing proteins in the sarcomeric Z-line. PALLD is ubiquitously expressed in several isoforms, and its longest 200 kDa isoform, predominantly expressed in striated muscle, shows high struc...

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Bibliographic Details
Main Authors: Giuseppina Mastrototaro, Pierluigi Carullo, Jianlin Zhang, Beatrice Scellini, Nicoletta Piroddi, Simona Nemska, Maria Carmela Filomena, Simone Serio, Carol A Otey, Chiara Tesi, Fabian Emrich, Wolfgang A Linke, Corrado Poggesi, Simona Boncompagni, Marie-Louise Bang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-03-01
Series:eLife
Subjects:
heart
cardiomyopathy
sarcomere
intercalated disc
palladin
myopalladin
Online Access:https://elifesciences.org/articles/78629

Internet

https://elifesciences.org/articles/78629

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