Accelerating clinical development of a live attenuated vaccine against Salmonella Paratyphi A (VASP): study protocol for an observer-participant-blind randomised control trial of a novel oral vaccine using a human challenge model of Salmonella Paratyphi A infection in healthy adult volunteers

Accelerating clinical development of a live attenuated vaccine against Salmonella Paratyphi A (VASP): study protocol for an observer-participant-blind randomised control trial of a novel oral vaccine using a human challenge model of Salmonella Paratyphi A infection in healthy adult volunteers

Introduction This is the first efficacy study of an oral live attenuated vaccine against Salmonella Paratyphi A using a human challenge model of paratyphoid infection. S. Paratyphi A is responsible for 3.3 million cases of enteric fever every year, with over 19 000 deaths. Although improvements to s...

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Bibliographic Details
Main Authors: Melanie Greenland, Elizabeth Jones, Xinxue Liu, Andrew J Pollard, Brian Angus, Susana Camara, Hannah Robinson, Marije Verheul, Jennifer Hill, Myron M Levine, Katherine Emary, Nisha Singh, Naina McCann, Florence Mclean, Young Chan Kim, Kerry Conlin, Maheshi N Ramasamy
Format: Article
Language:English
Published: BMJ Publishing Group 2023-05-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/13/5/e068966.full

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https://bmjopen.bmj.com/content/13/5/e068966.full

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