Genome-wide gene expression profiling of homeodomain-interacting protein kinase 2 deficient medullary thymic epithelial cells

Genome-wide gene expression profiling of homeodomain-interacting protein kinase 2 deficient medullary thymic epithelial cells

The establishment of central tolerance essentially depends on the promiscuous gene expression (pGE) of a plethora of tissue restricted antigens by the medullary thymic epithelial cells. The antigens are presented to developing thymocytes in the thymus to select for non-self reactive T-cell receptors...

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Bibliographic Details
Main Authors: Kristin Rattay, Jens Derbinski, Thomas G. Hofmann, Bruno Kyewski
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Genomics Data
Subjects:
Homeodomain-interacting protein kinase 2 (Hipk2)
Medullary thymic epithelial cell (mTEC)
Central tolerance
Autoimmune regulator (Aire)
Gene expression
Online Access:http://www.sciencedirect.com/science/article/pii/S2213596015001786

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http://www.sciencedirect.com/science/article/pii/S2213596015001786

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