Sample Size for Successful Genome-Wide Association Study of Major Depressive Disorder

Sample Size for Successful Genome-Wide Association Study of Major Depressive Disorder

Major depressive disorder (MDD) is a complex, heritable psychiatric disorder. Advanced statistical genetics for genome-wide association studies (GWASs) have suggested that the heritability of MDD is largely explained by common single nucleotide polymorphisms (SNPs). However, until recently, there ha...

Full description

Bibliographic Details
Main Authors: Jo Nishino, Hidenori Ochi, Yuta Kochi, Tatsuhiko Tsunoda, Shigeyuki Matsui
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Genetics
Subjects:
major depressive disorder
genome-wide association studies (GWAS)
semi-parametric hierarchical mixture model (SP-HMM)
effect-size distribution
genome-wide significance
sample size
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00227/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2018.00227/full

Similar Items