Sample Size for Successful Genome-Wide Association Study of Major Depressive Disorder

Sample Size for Successful Genome-Wide Association Study of Major Depressive Disorder

Major depressive disorder (MDD) is a complex, heritable psychiatric disorder. Advanced statistical genetics for genome-wide association studies (GWASs) have suggested that the heritability of MDD is largely explained by common single nucleotide polymorphisms (SNPs). However, until recently, there ha...

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Bibliographic Details
Main Authors: Jo Nishino, Hidenori Ochi, Yuta Kochi, Tatsuhiko Tsunoda, Shigeyuki Matsui
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Genetics
Subjects:
major depressive disorder
genome-wide association studies (GWAS)
semi-parametric hierarchical mixture model (SP-HMM)
effect-size distribution
genome-wide significance
sample size
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00227/full

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