Chronic Voluntary Morphine Intake Is Associated with Changes in Brain Structures Involved in Drug Dependence in a Rat Model of Polydrug Use

Chronic Voluntary Morphine Intake Is Associated with Changes in Brain Structures Involved in Drug Dependence in a Rat Model of Polydrug Use

Chronic opioid intake leads to several brain changes involved in the development of dependence, whereby an early hedonistic effect (liking) extends to the need to self-administer the drug (wanting), the latter being mostly a prefrontal–striatal function. The development of animal models for voluntar...

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Bibliographic Details
Main Authors: María Elena Quintanilla, Paola Morales, Daniela Santapau, Alba Ávila, Carolina Ponce, Pablo Berrios-Cárcamo, Belén Olivares, Javiera Gallardo, Marcelo Ezquer, Mario Herrera-Marschitz, Yedy Israel, Fernando Ezquer
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
animal model
neurodegeneration
opioid addiction
brain damage
neuroinflammation
polydrug
Online Access:https://www.mdpi.com/1422-0067/24/23/17081

Internet

https://www.mdpi.com/1422-0067/24/23/17081

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