A PAMPA Assay as Fast Predictive Model of Passive Human Skin Permeability of New Synthesized Corticosteroid C-21 Esters

A PAMPA Assay as Fast Predictive Model of Passive Human Skin Permeability of New Synthesized Corticosteroid C-21 Esters

The permeation properties of twenty newly synthesized α-alkoxyalkanoyl and α-aryloxyalkanoyl C-21 esters of standard corticosteroids: Fluocinolone acetonide, dexamethasone, triamcinolone acetonide and hydrocortisone were established using a PAMPA assay (70% silicone oil and 30% isopropyl myristate)....

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Bibliographic Details
Main Authors: Katarina D. Karljikovic-Rajic, Sote M. Vladimirov, Jadranka V. Odovic, Olivera A. Cudina, Bojan D. Markovic
Format: Article
Language:English
Published: MDPI AG 2012-01-01
Series:Molecules
Subjects:
corticosteroid C-21 esters
prodrug
PAMPA
membrane retention
permeation parameter
Online Access:http://www.mdpi.com/1420-3049/17/1/480/

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http://www.mdpi.com/1420-3049/17/1/480/

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