Imbalanced globin chain synthesis determines erythroid cell pathology in thalassemic mice
Background β-thalassemia occurs from the imbalanced globin chain synthesis due to the absence or inadequate β-globin chain production. The excessive unbound α-globin chains precipitate in erythroid precursors and mature red blood cells leading to ineffective erythropoiesis and hemolysis.Design and M...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ferrata Storti Foundation
2009-09-01
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| Series: | Haematologica |
| Online Access: | https://haematologica.org/article/view/5342 |