The Interplay of Hypoxia Signaling on Mitochondrial Dysfunction and Inflammation in Cardiovascular Diseases and Cancer: From Molecular Mechanisms to Therapeutic Approaches
Cardiovascular diseases (CVDs) and cancer continue to be the primary cause of mortality worldwide and their pathomechanisms are a complex and multifactorial process. Insufficient oxygen availability (hypoxia) plays critical roles in the pathogenesis of both CVDs and cancer diseases, and hypoxia-indu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/11/2/300 |
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| author | Esmaa Bouhamida Giampaolo Morciano Mariasole Perrone Asrat E. Kahsay Mario Della Sala Mariusz R. Wieckowski Francesco Fiorica Paolo Pinton Carlotta Giorgi Simone Patergnani |
| author_facet | Esmaa Bouhamida Giampaolo Morciano Mariasole Perrone Asrat E. Kahsay Mario Della Sala Mariusz R. Wieckowski Francesco Fiorica Paolo Pinton Carlotta Giorgi Simone Patergnani |
| author_sort | Esmaa Bouhamida |
| collection | DOAJ |
| description | Cardiovascular diseases (CVDs) and cancer continue to be the primary cause of mortality worldwide and their pathomechanisms are a complex and multifactorial process. Insufficient oxygen availability (hypoxia) plays critical roles in the pathogenesis of both CVDs and cancer diseases, and hypoxia-inducible factor 1 (HIF-1), the main sensor of hypoxia, acts as a central regulator of multiple target genes in the human body. Accumulating evidence demonstrates that mitochondria are the major target of hypoxic injury, the most common source of reactive oxygen species during hypoxia and key elements for inflammation regulation during the development of both CVDs and cancer. Taken together, observations propose that hypoxia, mitochondrial abnormality, oxidative stress, inflammation in CVDs, and cancer are closely linked. Based upon these facts, this review aims to deeply discuss these intimate relationships and to summarize current significant findings corroborating the molecular mechanisms and potential therapies involved in hypoxia and mitochondrial dysfunction in CVDs and cancer. |
| first_indexed | 2024-03-09T22:34:40Z |
| format | Article |
| id | doaj.art-4896c7642bac4da4bfd8c4fc98dfbaab |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T22:34:40Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-4896c7642bac4da4bfd8c4fc98dfbaab2023-11-23T18:51:07ZengMDPI AGBiology2079-77372022-02-0111230010.3390/biology11020300The Interplay of Hypoxia Signaling on Mitochondrial Dysfunction and Inflammation in Cardiovascular Diseases and Cancer: From Molecular Mechanisms to Therapeutic ApproachesEsmaa Bouhamida0Giampaolo Morciano1Mariasole Perrone2Asrat E. Kahsay3Mario Della Sala4Mariusz R. Wieckowski5Francesco Fiorica6Paolo Pinton7Carlotta Giorgi8Simone Patergnani9Department of Medical Sciences and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, ItalyDepartment of Medical Sciences and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, ItalyDepartment of Medical Sciences and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, ItalyDepartment of Medical Sciences and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, ItalyDepartment of Medical Sciences and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, ItalyLaboratory of Mitochondrial Biology and Metabolism, Nencki Institute of Experimental Biology of the Polish Academy of Sciences, 02-093 Warsaw, PolandDepartment of Radiation Oncology and Nuclear Medicine, AULSS 9 Scaligera, Ospedale Mater Salutis di Legnago, 37045 Verona, ItalyDepartment of Medical Sciences and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, ItalyDepartment of Medical Sciences and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, ItalyDepartment of Medical Sciences and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, ItalyCardiovascular diseases (CVDs) and cancer continue to be the primary cause of mortality worldwide and their pathomechanisms are a complex and multifactorial process. Insufficient oxygen availability (hypoxia) plays critical roles in the pathogenesis of both CVDs and cancer diseases, and hypoxia-inducible factor 1 (HIF-1), the main sensor of hypoxia, acts as a central regulator of multiple target genes in the human body. Accumulating evidence demonstrates that mitochondria are the major target of hypoxic injury, the most common source of reactive oxygen species during hypoxia and key elements for inflammation regulation during the development of both CVDs and cancer. Taken together, observations propose that hypoxia, mitochondrial abnormality, oxidative stress, inflammation in CVDs, and cancer are closely linked. Based upon these facts, this review aims to deeply discuss these intimate relationships and to summarize current significant findings corroborating the molecular mechanisms and potential therapies involved in hypoxia and mitochondrial dysfunction in CVDs and cancer.https://www.mdpi.com/2079-7737/11/2/300hypoxiaHIF-1αmitochondriaoxidative stressinflammationcardiovascular diseases |
| spellingShingle | Esmaa Bouhamida Giampaolo Morciano Mariasole Perrone Asrat E. Kahsay Mario Della Sala Mariusz R. Wieckowski Francesco Fiorica Paolo Pinton Carlotta Giorgi Simone Patergnani The Interplay of Hypoxia Signaling on Mitochondrial Dysfunction and Inflammation in Cardiovascular Diseases and Cancer: From Molecular Mechanisms to Therapeutic Approaches Biology hypoxia HIF-1α mitochondria oxidative stress inflammation cardiovascular diseases |
| title | The Interplay of Hypoxia Signaling on Mitochondrial Dysfunction and Inflammation in Cardiovascular Diseases and Cancer: From Molecular Mechanisms to Therapeutic Approaches |
| title_full | The Interplay of Hypoxia Signaling on Mitochondrial Dysfunction and Inflammation in Cardiovascular Diseases and Cancer: From Molecular Mechanisms to Therapeutic Approaches |
| title_fullStr | The Interplay of Hypoxia Signaling on Mitochondrial Dysfunction and Inflammation in Cardiovascular Diseases and Cancer: From Molecular Mechanisms to Therapeutic Approaches |
| title_full_unstemmed | The Interplay of Hypoxia Signaling on Mitochondrial Dysfunction and Inflammation in Cardiovascular Diseases and Cancer: From Molecular Mechanisms to Therapeutic Approaches |
| title_short | The Interplay of Hypoxia Signaling on Mitochondrial Dysfunction and Inflammation in Cardiovascular Diseases and Cancer: From Molecular Mechanisms to Therapeutic Approaches |
| title_sort | interplay of hypoxia signaling on mitochondrial dysfunction and inflammation in cardiovascular diseases and cancer from molecular mechanisms to therapeutic approaches |
| topic | hypoxia HIF-1α mitochondria oxidative stress inflammation cardiovascular diseases |
| url | https://www.mdpi.com/2079-7737/11/2/300 |
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