A new wave of innovations within the DNA damage response

Abstract Genome instability has been identified as one of the enabling hallmarks in cancer. DNA damage response (DDR) network is responsible for maintenance of genome integrity in cells. As cancer cells frequently carry DDR gene deficiencies or suffer from replicative stress, targeting DDR processes...

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Bibliographic Details
Main Authors: Qi Li, Wenyuan Qian, Yang Zhang, Lihong Hu, Shuhui Chen, Yuanfeng Xia
Format: Article
Language:English
Published: Nature Publishing Group 2023-09-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-023-01548-8