Simulating the Dynamic Intra-Tumor Heterogeneity and Therapeutic Responses

Simulating the Dynamic Intra-Tumor Heterogeneity and Therapeutic Responses

A tumor is a complex tissue comprised of heterogeneous cell subpopulations which exhibit substantial diversity at morphological, genetic and epigenetic levels. Under the selective pressure of cancer therapies, a minor treatment-resistant subpopulation could survive and repopulate. Therefore, the int...

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Bibliographic Details
Main Authors: Yongjing Liu, Cong Feng, Yincong Zhou, Xiaotian Shao, Ming Chen
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
tumor heterogeneity
clonal evolution
targeted therapy
treatment outcomes
simulation model
Online Access:https://www.mdpi.com/2072-6694/14/7/1645

Internet

https://www.mdpi.com/2072-6694/14/7/1645

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