Template-dependent DNA ligation for the synthesis of modified oligonucleotides
Abstract Chemical modification of DNA is a common strategy to improve the properties of oligonucleotides, particularly for therapeutics and nanotechnology. Existing synthetic methods essentially rely on phosphoramidite chemistry or the polymerization of nucleoside triphosphates but are limited in te...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-09-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-52141-8 |