Hierarchical Protofilament Intertwining Rules the Formation of Mixed‐Curvature Amyloid Polymorphs

Hierarchical Protofilament Intertwining Rules the Formation of Mixed‐Curvature Amyloid Polymorphs

Abstract Amyloid polymorphism is a hallmark of almost all amyloid species, yet the mechanisms underlying the formation of amyloid polymorphs and their complex architectures remain elusive. Commonly, two main mesoscopic topologies are found in amyloid polymorphs characterized by non‐zero Gaussian and...

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Bibliographic Details
Main Authors: Jiangtao Zhou, Salvatore Assenza, Meltem Tatli, Jiawen Tian, Ioana M. Ilie, Eugene L. Starostin, Amedeo Caflisch, Tuomas P. J. Knowles, Giovanni Dietler, Francesco S. Ruggeri, Henning Stahlberg, Sergey K. Sekatskii, Raffaele Mezzenga
Format: Article
Language:English
Published: Wiley 2024-08-01
Series:Advanced Science
Subjects:
amyloid polymorphism
atomic force microscopy
filament intertwining mechanism
mixed‐curvature amyloid
Online Access:https://doi.org/10.1002/advs.202402740

Internet

https://doi.org/10.1002/advs.202402740

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