Bacterial Quorum-Sensing Molecules as Promising Natural Inhibitors of Candida albicans Virulence Dimorphism: An In Silico and In Vitro Study

Bacterial Quorum-Sensing Molecules as Promising Natural Inhibitors of Candida albicans Virulence Dimorphism: An In Silico and In Vitro Study

Farnesol, a self-secreted quorum-sensing molecule (QSM) of Candida albicans, has been known to limit yeast-to-hyphal transition by blocking the RAS1–cAMP–PKA pathway. In a similar fashion, certain bacterial QSMs have also been reported to be successful in attenuating C. albicans biofilm and hyphal f...

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Bibliographic Details
Main Authors: Ravi Jothi, Nagaiah Hari Prasath, Shanmugaraj Gowrishankar, Shunmugiah Karutha Pandian
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
quorum-sensing molecules
farnesol
C. albicans
diketopiperazines
dimorphism
antihyphal
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.781790/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.781790/full

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