Recombinant human endostatin combined with radiotherapy promotes cardiomyocyte apoptosis in rats via TGFβ1/Smads/CTGF signaling pathway

Recombinant human endostatin combined with radiotherapy promotes cardiomyocyte apoptosis in rats via TGFβ1/Smads/CTGF signaling pathway

Abstract Purpose The aim of the present study was to investigate the efficacy of recombinant human endostatin (ES) (rh-ES) combined with radiation on rat cardiomyocyte apoptosis and the regulatory mechanism of transforming growth factor beta1 (TGF-β1)/Sma and Mad-related protein 3 (Smad3)/connective...

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Bibliographic Details
Main Authors: Weiwei Ouyang, Shimei Fu, Xing Zhao, Shengfa Su, Jun Zhang, Daxian Luo, Lina Liu, Wenjin Ding, Dongdong Cao, Likun Liu, Zhixu He, Bing Lu
Format: Article
Language:English
Published: BMC 2022-03-01
Series:BMC Cardiovascular Disorders
Subjects:
Recombinant human endostatin
Radiotherapy
Signaling pathway
Apoptosis
Lung cancer
Online Access:https://doi.org/10.1186/s12872-022-02499-8

Internet

https://doi.org/10.1186/s12872-022-02499-8

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